Azadirachtin can help immune cells fight tumor

Recently, Zhu Shiguo's team from the school of basic medicine of Shanghai University of traditional Chinese Medicine published the research results of Dr Yao Chao as the first author in the international academic journal autophagy online, which showed that neem enhanced the killing effect of natural killer cells (NK cells) on non-small cell lung cancer cells The research results have been applied for national invention patents NK cell immunotherapy is a promising new method of tumor immunotherapy, but the immune escape of cancer cells limits the clinical effect of NK cells How to improve the antitumor effect of NK cells is an important front topic of tumor immunotherapy Zhu Shiguo's team has an in vitro expansion technology of NK cells with independent intellectual property rights, which can guarantee the clinical supply of NK cells in number In order to find out the Chinese herbal active ingredients that can improve the anti-cancer effect of NK cells, the team has established a variety of high-throughput screening systems, and found a variety of Chinese herbal active ingredients with potential development value through these systems This time, after a large number of screening and strict identification, the team found out from thousands of active ingredients of traditional Chinese medicine that azadiramide, the active ingredient of mizilan, has a good ability to improve the anti-tumor effect of NK cells It has been found that azadiramide can bind to the specific sequence of untranslated region of RNA5 'of ulk1 Messenger, inhibit the protein translation of ulk1, further inhibit the autophagy of tumor cells, improve the level of granzyme B from NK cells in tumor cells, thus block the autophagy mediated tumor immune escape, and ultimately improve the killing effect of NK cells on tumor cells The results of this study have important application prospects in tumor immunotherapy, especially in NK cell immunotherapy It is understood that mizilan is an evergreen shrub or small tree belonging to mizilan of Meliaceae, which is native to South China Its chemical composition includes lignans, diamides, etc The branches and leaves of mizilan are used as medicine to treat bruises and carbuncle The flower is used for depression of Qi, depression of chest and stagnation of food (BIOON Com)