Authoritative interpretation by experts: a reasonable choice of metformin dual oral hypoglycemic drugs

"Cardiovascular disease is the main cause of death for

Only by reducing blood sugar and reducing cardiovascular events can the prognosis be improved

Professor Xu Chun emphasized in the course "The Reasonable Choice of Metformin Dual Oral Hypoglycemic Drugs" that the harm of diabetes to the human body is mainly the complications caused by high blood sugar

In recent years, the academic circles have gradually shifted from "simply controlling blood sugar" to "lowering blood sugar while reducing cardiovascular events and improving prognosis"

Reasonable choice of dual oral hypoglycemic drugs based on metformin

Professor Xu Chun introduced that some western medicines such as metformin rarely have hypoglycemia when used alone to lower blood sugar, and they can also reduce weight and have cardiovascular benefits

"China Type 2 Diabetes Prevention Guidelines (2020 Edition)" pointed out that the use of a hypoglycemic agent to treat blood sugar failures should be combined with two or even three hypoglycemic drugs with different mechanisms of action

When to start oral hypoglycemic drug combination therapy? Professor Xu Chun introduced that oral hypoglycemic drug combination therapy can be initiated under four conditions:

Professor Xu also gave specific instructions for the specific plan of the combination drug and the respective applicable populations and advantages and disadvantages:

"China's Type 2 Diabetes Prevention Guidelines (2020 Edition)" clearly recommends: for patients with type 2 diabetes, on the basis of the application of metformin and other hypoglycemic drugs, plus

Similar to the same result, taking into account the occurrence of diabetes complications is the key to lowering blood sugar

In response to the occurrence of chronic complications of diabetes, Professor Xu Chun pointed out that overnutrition will inhibit AMPK signaling pathway, block catabolism, and activate mTORC1 signaling pathway to promote anabolism

Metformin can activate the AMPK pathway, inhibit the mTORC1 signaling pathway, and improve the imbalance of energy metabolism

A domestic clinical study also confirmed that Jinlida particles can reduce early renal damage in T2DM, reduce urine microalbumin, reduce the thickness of the carotid artery intima and media, protect large blood vessels, and prevent complications such as diabetic nephropathy and diabetic cardiovascular and cerebrovascular diseases.

Traditional Chinese medicine is people-oriented and emphasizes the concept of integrity and prevention of disease

Focus on chronic disease management at the grassroots level to help healthy China

At present, it is estimated that the total number of diabetic patients in China has exceeded 129 million, and the number of pre-diabetic patients is 357 million, making it the country with the largest number of diabetic patients in the world

The “Healthy China, Empowering County” project is a national public welfare project to improve the diagnosis and treatment level of primary health workers and general practitioners in county and urban communities in the industry

This issue of "A Reasonable Choice of Metformin Dual Oral Hypoglycemic Drugs" course attracted nearly 10,000 doctors from across the country to gather online