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Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial, Published:July 26, 2021DOI:https ://doi.
Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial, Published:July 26, 2021DOI:https ://doi.
"The Lancet -Infectious Diseases" published the results of a phase I clinical study of the adenovirus vector recombinant neocorona vaccine (adenovirus vector type 5) (Ad5-nCoV) developed by the team of Academician Chen Wei of the Academy of Military Sciences
immunity
Ad5-nCoV vaccination caused adverse events, active adverse events reported within 7 days after Ad5-nCoV immunization (A) and booster (B) vaccines
Ad5-nCoV vaccination caused adverse events, active adverse events reported within 7 days after Ad5-nCoV immunization (A) and booster (B) vaccines
The test results showed that the intramuscular injection group (including the mixed immunization group) (49/78, 63%) had more adverse events than the nebulized inhalation group (13/52, 25%) within 7 days after the first immunization.
Serum IgG, IgA and neutralizing antibody response after Ad5-nCoV vaccination
Specific cellular immune response to SARS-CoV-2 spike protein after Ad5-nCoV vaccination
The paper concluded that nebulized Ad5-nCoV was well tolerated, and two doses of nebulized Ad5-nCoV caused a neutralizing antibody response, similar to one dose of intramuscular injection
At the same time, the dose of aerosolized inoculation of Ad5-nCoV is equivalent to 1/5 of the required dose of intramuscular injection, which can induce strong humoral and cellular immunity
CCTV News
CCTV NewsNebulized inhalation immunity is the use of a nebulizer to atomize the vaccine into tiny particles, which enter the respiratory tract and lungs through breathing inhalation, thereby stimulating mucosal immunity, which cannot be brought by intramuscular injection, usually through muscles The injected new crown vaccine can only induce humoral immunity and cellular immunity
Schematic diagram of aerosol inhalation immunity equipment, Bennett JV, Fernandez de Castro J, Valdespino-Gomez JL, et al.
Schematic diagram of aerosol inhalation immunity equipment, Bennett JV, Fernandez de Castro J, Valdespino-Gomez JL, et al.
Nebulization of measles vaccine is the most promising method of non-subcutaneous injection methods.
The difference in titer between nebulized inhalation and injection, Bennett JV, Fernandez de Castro J, Valdespino-Gomez JL, et al.
Bennett JV, Fernandez de Castro J, Valdespino-Gomez JL, et al.
When the atomized dose is less than or equal to one-fifth of the usual injection dose, this advantage still exists
First, the vaccine does not need to be injected.
manage
On July 28, CanSino Bio revealed to the media that the Phase II clinical study of the nebulized inhaled new crown vaccine is ongoing
.
Reference materials:
1.
Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial, Published:July 26, 2021DOI : https://doi.
org/10.
1016/S1473-3099(21)00396-0.
org/10.
1016/S1473-3099(21)00396-0.
COVID-19
2.
Bennett JV, Fernandez de Castro J, Valdespino-Gomez JL, et al.
Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican schoolchildren.
Bulletin of the World Health Organization.
2002; 80(10):806-812.
PMID: 12471401
Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican schoolchildren.
Bulletin of the World Health Organization.
2002 ;80( 10):806-812.
PMID: 12471401
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