Professor Tong Zhiqian of Capital Medical University, Professor Han Hongbin of Peking University Third Hospital, and their collaborators found that the movement and coordination problems observed in mice that have been active for several weeks in a simulated microgravity environment may be due to the mouse’s legs and brain The accumulation of the compound formaldehyde has occurred
Some astronauts will experience muscle weakness and movement problems after returning to Earth, and it may take several weeks to learn to walk again
In the new study, the author suspends the hind limbs of 8 adult mice for 2 weeks to simulate a microgravity environment
They found that mice lacking formaldehyde decomposing enzymes had less balance and coordination on the balance beam and rotating rod than control mice, and that injection of formaldehyde into the cerebellum of healthy mice was also related to decreased coordination
The author's hypothesis is that excessive levels of formaldehyde may harm the cerebellum and muscles, thereby affecting balance and coordination
Related paper information: https://doi.
https://doi.
org/10.
1038/s42003-021-02448-9 https://doi.
org/10.
1038/s42003-021-02448-9
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