Astrogenic glial cells promote the proliferation of glioblastoma

Glioblastoma (GBM) is a type of malignant brain tumor with a high mortality rate.
the micro-environment of glioblastoma can affect tumor progression.
in the micro-environment of GBM, macrophages, small glial cells, astrocytes and cells around blood vessels affect the development of GBM by migration, invasion, angiogenesis and therapeutic anticococcy.
glial cells account for about 50% of brain cells, there is not much research on the role of star glial cells in GBM micro-environment.
Alessandro Mega of Oncology Pathology at Karolinska College in Stockholm, Sweden, used clinical tumor samples for in vitro and in vivo experiments to determine the effect of astrocytes on the proliferation of glioblastoma.
results were published online in September 2019 in Glia.
results The study first designed and evaluated the scoring criteria for the characteristics of astrology glial cells and analyzed the distribution of astrology glial cells in 561 cases of GBM tumors in the cancer genome map (TCGA) GBM data.
, the authors found a significant positive correlation between astrogenic glial cell feature scores and unmethylated MGMT initiaters (p-0.032).
survival analysis of TCGA GBM showed that patients with high astrogenic glial cell characteristic scores had significantly short survival periods (p-0.037).
analysis of multivariate survival using Cox proportional risk model showed that the high expression of bone membrane protein (POSTN) with ascental glial cell characteristic score was significantly correlated with shorter survival time (HR=1.37; 95% CI, 1.06-1.77; p=0.017).
Through co-culture technology to study the potential of astrogenic glial cells to promote GBM growth, it was found that astrology glial cells have the ability to enhance the growth of a variety of GBM cell line and GBM cells derived from patients, star glial cells by side secretion to induce GBM cell blocking in the cell cycle S period.
in immunodeficiency mice (NOD scid mice) models, injection of asstary glial cells and glioblastoma cells significantly reduced survival in NOD scid mice.
the results suggest that astrocyte-induced GBM cell proliferation is an important biological feature of GBM, which can lay the foundation for the corresponding new GBM treatment.
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