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AstraZeneca launches first phase II study for first-line treatment of pancreatic ductal adenocarcinoma

 Last Update: 2021-09-05
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Shi Bei

Recently, AstraZeneca registered the first-in-class anti-LIF monoclonal antibody AZD0171 (MSC-1) combined with anti-PD-L1 monoclonal antibody duvalizumab and chemotherapy (gemcitabine and albumin-bound paclitaxel) on the American Clinical Network Phase II clinical trial for the treatment of pancreatic ductal adenocarcinoma (PDAC)

The study is an open-label, single-arm, multi-center phase II study.

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine involved in a variety of physiological and pathological processes

AZD0171 is a first-in-class fully human anti-LIF monoclonal antibody purchased by AstraZeneca from Northern Biologics, which can effectively and selectively inhibit LIF

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