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ASH 2021: The second-line Axicabtagene Cilouleucel treats relapsed/refractory DLBCL with better efficacy

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL) in the United States and worldwide, accounting for approximately 22% of newly diagnosed B-cell NHL cases in the United States.
In the United States, there are more than 18,000 people have been diagnosed with DLBCL
.

Lymphoma diagnosis

In the preliminary analysis of the ZUMA-7 trial, axicabtagene ciloleucel (axi-cel) showed an advantage over standard treatment in patients with relapsed/refractory large B-cell lymphoma (DLBCL), and the median event-free survival rate increased by 4 The 2-year event-free survival rate is increased by 2.
5 times, and the complete remission rate is doubled
.

axi-cel is expected to become a new choice for patients with second-line relapsed/refractory large B-cell lymphoma

ZUMA-7 includes 359 early (≤12 months) patients with relapsed/refractory large B-cell lymphoma who plan to undergo stem cell transplantation after receiving first-line chemotherapy
.

Patients were randomly assigned pretreatment chemotherapy axi-cel (n = 180) or the researchers chose platinum-based chemical immune therapy (= n-179)

Stem Cell Immunity

After a median follow-up time of 24.
9 months, the median event-free survival time of axi-cel was 8.
3 months, compared with 2 months for patients receiving standard treatment
.

The objective response rate of the axi-cel group was 83%, while that of the standard treatment group was 50%

After a median follow-up time of 24.

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