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ASCO2021: Immune expression signals can predict treatment response and survival of metastatic colorectal cancer

 Last Update: 2021-06-16
 Source: Internet
 Author: User

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According to the 2021 annual ASCO annual meeting of the CALGB / SWOG 80405 Test ( Abstract 3515) analyzed tumor immunity signal influences metastatic colorectal colorectal cancer (of mCRC) response to treatment and survival

According to the 2021 annual ASCO ASCO annual meeting of the CALGB / SWOG 80405 Test ( Abstract 3515) analyzed tumor immunity signal influences metastatic colorectal colorectal cancer immunization of colorectal cancer (of mCRC) response to treatment and survival

The randomized phase III trial compared the first-line situation of bevacizumab combined with chemotherapy, cetuximab combined with chemotherapy, and two drugs combined with chemotherapy ; no difference was found in overall survival (OS) .

In all studies, when the beneficial signal is reduced, the OS is significantly reduced

Bevacizumab group, only the M2 signal expressing macrophages increase shorter OS correlation (the HR 6.

In cetuximab group, there are 4 in patients salutary signal OS does not reach, including 3 in patients of such signals OS of 39.

In the bevacizumab group, only the M2 macrophage signal was significantly correlated with OS , the median OS with beneficial signals was 34.

Innocenti said Dr.

However, Dr.
Cleary believes that these biomarkers need further research and verification.
This study shows that careful collection of samples in clinical trials is essential to improve understanding of these and other therapies
.

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