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ASCO: Phase 2 study of continuous talazopanib (TALA) plus intermittent low-dose temozolomide (TMZ) in patients with relapsed or refractory extensive-stage small cell lung cancer

 Last Update: 2022-08-10
 Source: Internet
 Author: User

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Background: Talazopanib (TALA) inhibits cytotoxic effects by inhibiting poly ADP-ribose polymerase (PARP) proteins 1 and 2 and "trapping" PARP on D.

Talazopanib (TALA) Talazopanib (TALA) Temozolomide (TMZ) Temozolomide ( TMZ) Second-Line Therapy for ES-SCLC

Methods: This study is an open-label, single-arm, phase 2 study of the safety and efficacy of TALA plus TMZ in ES-SCLC patients refractory/relapsed to first-line platinum-based regime.

TALA plus TMZ treatment

The primary outcome measure was objective response rate (ORR) based on RECIST 1 criteria, 15% ORR for previous second-line topotecan as control, and 8 or more confirmed responses in 28 evaluable subjects (29% ORR) were achiev.

Objective Response Rate (ORR)

RESULTS: A total of 31 subjects were included, 3 of whom could not be assessed due to ineligibility or premature withdrawal of consent prior to the first disease assessme.

Conclusion: The study exceeded its target response rat.

Benefits of low-dose TMZ inhibition of PARP beyond its target response rate

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