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ASCO-2021 Express: Harvard University: Breast Cancer Drugs Can Extend Progression-Free Survival of Glioblastoma

 Last Update: 2021-06-10
 Source: Internet
 Author: User

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In most glioblastomas, the cyclin D-CDK4/6-Rb pathway is activated.

Breast cancer

In order to effectively evaluate the potential impact of Abemaciclib on the overall survival (OS) of newly diagnosed glioblastoma, and at the same time to develop information about potential genomic biomarker associations, Abemaciclib is listed as an innovative glioblastoma therapy personalized A test group of the screening test (INSIGhT).

diagnosis

And explored the relationship between the efficacy of Abemaciclib and cyclin D-CDK4/6-Rb pathway genome changes.

However, compared with the control group (median 15.

The core conclusion of this RCT: Abemaciclib is well tolerated and prolongs PFS, but there is no evidence that compared with standard radiotherapy and chemotherapy, overall survival has improved.

Abemaciclib is well tolerated and prolongs PFS, but there is no evidence that compared with standard radiotherapy and chemotherapy, overall survival has improved.

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