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Ascletis announced that the clinical trial application for ASC11, an oral 3CLpro inhibitor, has been accepted by the NMPA

 Last Update: 2023-01-01
 Source: Internet
 Author: User

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Ascletis Pharmaceuticals Limited (HKEx: 1672, "Ascletis") today announced that its application for clinical trial (IND) for ASC11, an oral candidate for COVID-19 ("COVID-19") oral candidate (3CLpro), has been accepted
by the National Medical Products Administration of China ("NMPA").

In antiviral cell experiments infected with the new coronavirus, ASC11 showed much higher anti-novel coronavirus activity
than other 3CLpro inhibitors such as nirmatevir, S-217622, PBI-0451 and EDP-235.
ASC11 maintains potent antiviral activity
against a variety of widely circulating Omicron variants such as BA.
1 and BA.
5.
In animal models of novel coronavirus infection, ASC11 also exhibits potent antiviral activity
.

ASC11 is an oral small molecule candidate independently developed using a variety of proprietary technologies, including molecular simulation docking
.
Ascletis has filed patent applications
worldwide for ASC11 and related compounds and their use in the treatment of viral diseases.

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