Arthritis Rheumatol: Skin Manifestations of Anti-Neutral Granulocytes Cell Plasma Antibodies Associated With Vascularitis

The skin performance of anti-neutral granulocytes cell plasma antibody-associated vasculitis (AAV) was not well characterized, including granuloma combined with polyvascularitis (GPA), multivasitis under the microscope (MPA) and eosinophilic granuloma combined with polyvasitis (EGPA)The study describes aAAV's dermatological characteristics and their association with the overall performance of vasculitisa cross-sectional study that describes and compares skin performance of AAVs from a large international collaborative study that collects comprehensive clinical data on patients with vasculitisdata from 1,184 AAV patients in 130 centers around the world could be used for the studySkin performance is common in all AAV subtypes: GPA (223/656; 34%), MPA (85/302; 28%) and EGPA (106/226; 47%)。 The most common skin manifestation in AAVs (all types) is plaque/cyanosis (N-181;15%)Variability and nonspecific manifestations, such as itching, urticaria and papules, are more common in EGPA than other subtypes (p.01)Although the use of skin biopsies is low (22-44%), it is usually diagnostic (68-94%)the manifestation sileremum systemic vasculitis is more common in patients with skin lesions (e.galveoli hemorrhage and glomerular glomerinitis), especially in patients with GPA or EGPA, and patients with cytoplasm/anti-PR-3 ANCA or ANCA negative (both risk ratios of 1.9), except for patients with MPA or nuclear week/anti-AmANCAskin is common and different in AAVsIn GAV, EGPA, cytoplasm/anti-PR3 ANCA-positive or ANCA-negative patients, skin performance is associated with the severity of the diseaseThese findings highlight the potential diagnosis and prognosis of skin testing in AAV assessment and treatment