Arthritis Rheumatol: Lung function check in patients with interstitial lung disease in patients with early diffuse skin SSc
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Last Update: 2020-07-10
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Source: Internet
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Author: User
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Interstitial pulmonary disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc)Although lung function tests (PFTs) are commonly used forscreeningILD in Patients with SSc, studies have shown that PFTs are less sensitive to ILD in the general SSc queueThe purpose of this study was to assess the performance characteristics of ILD in patients with early diffuse skin (dc) SSc, while patients with early diffuse skin SSc were at high risk of ILDconducted a retrospective cohort study of patients enrolled in the prospective registration of early systemic sclerosis at 11 locations in the United States from April 2012 to January 2019Patients who received lung capacity measurements and chest high-resolution CT (HRCT) were included in the studyThe performance characteristics of THE PFT detection OF ILD on HRCT were calculatedincluded 212 patients; For detecting ILD on HRCT, the sensitivity of force lung capacity (FVC) as a percentage of the forecast was 63%FVC 80% of the estimated value of the combined DLCO 80% of the estimate increases the sensitivity to 85%The negative prediction value (NPV) of the FVC 80% forecast value is 61%, while the FVC 80% forecast value is 70% of the NPV of the 80% forecast valuefor early dSSc patients, a lung function test alone is not enough to screen for ILDFor dcSSc patients, HRCT should be part of ILD screening
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