Arthritis Rheumatol: Endoderic and inflammatory biomarker characteristics at diagnosis can predict the therapeutic response of juvenile dermatitis

Adolescent dermatitis (
JDM) is a heterogeneous systemicimmunemediatedvasculardisease, the objective of this study is:1) to determine the inflammatory/
endothelial dysfunction associated with theofdiagnosis of biomarker characteristics;2) to determine whether biomarker characteristics can predict therapeutic responsesused multiple techniques to determine 39 markers in serum from two independent cohorts JDM first treatment (
n?30/n?29 ) and were associated with endothelial activation, dysfunction and inflammation The analysis of treatment duration uses the Kaplan-Meier and Cox proportional risk models for non-parametric testing of data through unsupervised hierarchical clustering and correction of multiple tests Myocarditis-specific antibodies (
MSA ) are determined by wire marking severe vascular lesions were associated with low ICAM-1 (
rs s.0.465 , p s 0.0111 ) and high endothelial factors (
rs ?0.67 , p 0.0001 ) Unsupervised clustering of all markers resulted in two different patient categories: smaller categories (
n-8 ), higher levels of CXCL13 , CCL19 , semi-lactose -9 , CXCL10 , TNFR2 and semi-lactose -1 (
.0001 ) In the validation queue, the correlation between the -9 , the CXCL10 , the TNFR2 and the of the -1 of the semi-lactosin and the activity of the whole disease was confirmed (
rs s 0.40-0.52 , p 0.05 ) These 4
markers are used to stratify patients to identify patients with severe symptoms and patients who need more in-depth treatment in the first 3 months (
64.7 % vs.34.1 %, p.0437 ) Semi-lactosin -9 , CXCL10 and TNFR2 can predict longer duration of treatment (
p 0.05 ) There was no significant correlation between the classification of biomarkers and the serotype of MSA this study uses serum biomarkers to confirm the heterogeneity of the new JDM Patients with -9 , CXCL10 , TNFR2 and semi-lactose -1 may not respond well to conventional treatment and may benefit from more in-depth monitoring and /
or treatment