Arthritis Rheumatol: Effect of increased dose of perprecand alcohol on bone erosion and urate levels in gout patients

The purpose of this study was to explore whether the increase in dose of persinatin to achieve serum uric acid (SU) indicators affected bone erosion or the deposition of sodium uric acid (MSU) crystalswe conducted a 2-year imaging study of a randomized clinical trial that compared gout patients who received peripurpial alcohol and SU levels, immediately increased the dose of peripurinol to The SU target for 1 year with the conventional administration, and then increased the dose to the target 0.36 mM/LAt baseline, DECT foot scans and hand and foot X-rays were performed at the first and second years of patient visitsBone erosion and urate levels of DECT scans were gradedresults, matching imaging data for 87 patients was obtained (42 in the dose increment group and 45 in the control group)In year 2, the CT erosion score in the control group progressed higher than in the dose-increasing group (.7.8% VS plus 1.4%; P was 0.015)There was no difference in changes or narrow scores of radiation erosion or scoring between the two groupsA decrease in DECT uric acid levels was observed in both groupsIn the second year, the amount of DECT urate decreased (-27.6 to -28.3%) in patients with SU levels of 0.36 mM/L in the control group and patients in the dose-increasing group( and the decT urate amount was not reduced in the control group of Patients with SU-0.36 mM/L (P -0.023)in general, these findings provide evidence that even long-term urate-reducing therapy with SU-targeted treatment strategies can affect structural damage and reduce the deposition of urate crystals in gout