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Arnold Pharma submits a clinical trial application for the self-developed oral PD-L1 inhibitor AN4005

 Last Update: 2021-07-06
 Source: Internet
 Author: User

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Arnold Pharma, an innovative global biopharmaceutical company focusing on the field of tumor treatment, today announced that it has submitted a clinical trial application (IND) for its original innovative drug oral PD-L1 inhibitor AN4005 to the U.
S.
Food and Drug Administration (FDA)
.

Arnold Pharma will carry out a phase I clinical trial for the safety and pharmacokinetic evaluation of the drug, and patient enrollment will also be initiated in the United States

As an orally active specific PD-L1 antagonist, AN4005 has shown strong anti-tumor activity before clinical
.

AN4005 can effectively induce and stabilize the formation and dimerization of PD-L1 dimers, thereby effectively destroying the interaction between PD-1/PD-L1 proteins

"As a small molecule PD-L1 inhibitor, AN4005 has shown good anti-tumor activity, and has great potential in monotherapy and in combination with other products of the company in the future
.

The feature of its oral administration is in Combination drugs will have a strong competitive advantage

As an alternative to monoclonal antibodies, small molecule PD-(L)1 inhibitors have gradually attracted more attention in the field of tumor immunotherapy
.

Compared with monoclonal antibodies, small molecule PD-(L)1 inhibitors are expected to bring greater benefits.

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