Are allergic to meat only vegetarian?

The gene-edited pig "GalSafe Pig" developed by the American medical company Revivicor was approved by the U.

In addition, "GalSafe pig" can also be used to produce drugs similar to heparin, and its tissues and organs may potentially solve the problem of immune rejection after xenotransplantation of patients

"'GalSafe pig' was approved for listing, marking the first time that a gene-edited animal has achieved dual use for food and medicine

A variety of gene-edited animals have been approved for marketing

The first approval of a genetically modified animal for both food and potential biomedical use is a huge milestone in scientific innovation

This is the first time that the FDA has approved genetic changes in animals for human food consumption and potential therapeutic use.

Which gene-edited animals have been approved for marketing in the United States and other countries? Jiang Tao pointed out that there are currently several gene-edited animals approved by developed countries in foreign biotechnology

In 2014, the FDA approved the marketing of a gene-edited rabbit that can be used to produce drugs for the treatment of hereditary angioedema

"In 2015, a gene-edited chicken developed by the Rosslyn Institute in Cambridge, UK, that can make recombinant protein drugs in eggs was approved by the FDA for the treatment of human genetic diseases that cannot degrade cell fat.

Remove the corresponding genes to truly prevent allergies

GalSafe means galactose safe.

Alpha-galactose is only found in mammals, but not in humans

Why can we prevent allergies only by knocking out related genes? Can we not avoid allergies through cooking? In this regard, Jiang Tao explained that some foods cause allergies after human consumption, indicating that allergen molecules or parts of the food in the food bind to the special immune receptors of human intestinal epidermal cells, triggering a type of acute stress response

"Such allergic conjugates have often been partially digested by various digestive enzymes in the gastrointestinal tract, gastric juice, pancreatic juice, and intestinal juice.

Tang Bo, Ph.

The breeding conditions of "GalSafe Pigs" are much stricter than those of traditional pigs.

Medical gene-edited animals cannot be replaced

Since the first gene-edited mouse was born in the early 1980s, gene editing technology has developed rapidly, and gene-edited cattle, sheep, fish, and insects have appeared one after another

The FDA also stated that any institution or research institute must seek further FDA approval before using "GalSafe pigs" for new drugs or human implants

Although "GalSafe Pig" is not the first gene-edited animal to be approved for marketing, it is the first to be approved to use gene-edited animals for food and medical purposes
.
So, which is more important to study gene-edited animals, food or medical use?

"Specific analysis of specific issues cannot simply compare which is more important
.
At present, there are more researches on medical genetically modified animals, mainly for the production of recombinant protein drugs, human disease models, heterogeneous organ donors, etc.
The
genetically modified'GalSafe pig' It can be used to produce pork products that are not allergic to people suffering from α-galactose syndrome, and more importantly, it is used to produce medical products that are not prone to immune rejection, such as extracting drugs from pigs, xenotransplanted organs, cells and other products
"Tang Bo said
.

Because it does not contain detectable galactose, "GalSafe pig" may be used as a blood thinner-heparin and other medical products
.
The tissues and organs of the "GalSafe pig" may also solve the problem of immune rejection in xenotransplant patients, because α-galactose is considered to be one of the reasons for patient rejection
.

Jiang Tao pointed out that gene-edited animals are of great value for both food and medical use, and medical use is an irreplaceable new use
.

"Because our food animals have now been intensively raised, and the cost is close to the ceiling.
The current genetic modification can improve the feed return rate, lean meat rate, disease resistance, etc
.
.
For medical use, especially the use of special gene-edited pigs as xenogeneic organ transplants The donors of AIDS are an unprecedented new field.
Once successfully realized, it is expected to completely reverse the shortage of organs used to treat human organ failure leading to death and save the lives of a large number of patients
.
” Jiang Tao said
.