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ARD: The Huayinghui team revealed that type II collagen promotes gouty arthritis by regulating sodium urate crystals and inflammatory cell recruitment

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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On September 15th, the Hua Yinghui team of the Department of Sports Medicine of Huashan Hospital affiliated to Fudan University carried out research based on clinical surgical experience, combined with nonlinear optics, rheumatic immunity, image processing and other fields, and the latest research results were based on Type II collagen facilitates gouty arthritis by regulating MSU crystallization and cellinflammatoryRecruitments ("Type II Collagen Promotes Gout Arthritis by Regulating Sodium Urate Crystals and Inflammatory Cell Recruitment") was published

The study found that type II collagen in synovial fluid is an important pathophysiological factor

On the other hand, transcriptomic analysis and in vitro and in vitro molecular biology experiments confirmed that II collagen peptide enhances sodium urate-mediated innate immune cell chemotaxis and recruitment by activating the integrin β1 (ITGB1)-dependent TLR2/4-NF-κB signaling pathway, which ultimately promotes the crystal-related inflammatory cascade; After selective silencing of key molecules in the pathway, type II collagen-enhanced sodium urate-mediated inflammation can be partially suppressed

Dr.

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Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment

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