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ARD: stage-specific roles of dysbiosis and metabolic disturbances in rheumatoid arthritis

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Objective: Rheumatoid arthritis (RA) is a progressive disease comprising four stages in which the gut microbiome is associated with pathogenesis

Methods: We investigated the fecal metagenome and plasma metabolome of 76 RA patients, 19 osteoarthritis patients, and 27 healthy individuals classified into four stages (stages I-IV) based on the 2010 RA classification criteria

RESULTS: First, homogeneous Bacteroides and Bacteroides depletion impaired glycosaminoglycan metabolism (p<0.

Conclusions: Clinical microbiological interventions should consider RA stages, in which dysbiosis and metabolic disturbances exhibit distinct patterns and play a stage-specific role

Source: Cheng M, Zhao Y, Cui Y, et al.

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