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ARD: lifetime risk of interstitial lung disease associated with rheumatoid arthritis in MUC5B mutation carriers

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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Purpose: Interstitial lung disease (ILD) is one of the most common extra-articular complications of rheumatoid arthritis ( RA )
.

The MUC5B promoter variant rs35705950 is an important risk factor for inherited ILD .

Objective: interstitial lung disease (ILD) is one of the most common rheumatoid arthritis ( rheumatoid arthritis RA outer) articular complications

Methods: FinnGen is a collection of epidemiological cohorts and hospital biobank samples, combining genetic data with 50 years of follow-up by the

Results: 293 972 individuals were in 1965 Ming (0.
7%) in 80 developing at the age of ILD

Conclusion: The results of this study provide lifetime risk estimates of RA-ILD based on the status of MUC5B MUC5B mutation carriers , and demonstrate the potential of genomics for RA-ILD risk stratification .
Further research is needed to investigate the effect of MUC5B and MUC5B on RA-ILD results .

Source:

Palomäki A, et al.

Ann Rheum Dis 2021;80:1530–1536.
doi:10.

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