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ARD: Efficacy and Safety of the Selective TYK2 Inhibitor Decavatinib in a Phase II Trial of Psoriatic Arthritis

 Last Update: 2022-08-15
 Source: Internet
 Author: User

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Objective : To evaluate the efficacy and safety of the oral selective tyrosine kinase 2 (TYK2) inhibitor decavatinib in patients with active psoriatic arthritis (PsA.

Objective To evaluate the efficacy and safety of oral selective tyrosine kinase 2 (TYK2) inhibitor decavatinib in patients with active psoriatic arthritis (PsA.

Methods : In this double-blind phase II trial, 203 patients with PsA were randomly assigned in a 1:1:1 ratio to placebo, decavatinib 6 mg once daily, or 12 mg once dail.

Methods In this double-blind phase II trial, 203 patients with PsA were randomly assigned in a 1:1:1 ratio to placebo, decavatinib 6 mg once daily, or 12 mg once dail.

Results At Week 16 , ACR-20 for decavatinib 6 mg once daily (59%, p=0134) and 12 mg once daily (67%, p=0004) compared to placebo (38%) The response was significantly highe.

CONCLUSIONS : Treatment with the selective TYK2 inhibitor decavatinib was well-tolerated and had greater effects than placebo on ACR-20 , multiple-controlled secondary endpoints, and other exploratory efficacy measures in patients with Ps.

Mease PJ, Deodhar AA, van der Heijde D , et a.
Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthrit.
Annals of the Rheumatic Diseases2022; 81: 815-82 , et al Annals of the Rheumatic Diseases81: leave a message here

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