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ARD: Deletion of Mesenchymal Activin A Ameliorates Disease Severity in Experimental Arthritis

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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ana rheumatoid arthritis

rheumatoid arthritis pathophysiology

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OBJECTIVE: The aim of this study was to assess the extent and mechanism of activin A leading to progressive joint destruction in experimental arthritis and which cell types expressing activin A are important for disease progressio.

Methods: Levels of activin A in synovial tissue were assessed by immunohistochemistry, cell-specific expression and secretion by PCR and ELISA, respectivel.

Results: In this study, researchers demonstrated that fibroblast-like synoviocytes (FLS) are the major producers of activin A in arthritic joint.

Conclusions: The results highly suggest that FLS-produced activin A plays a crucial paracrine role in inflammatory joint destruction and may be useful in the treatment of inflammatory diseases (such as rheumatoid arthritis) associated with OC formation and bone destructio.

Source:

Waltereit-Kracke V, Wehmeyer C, Beckmann D, et a.

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