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On-demand manufacturing: 3D printing is different from the traditional formulation process.
This technology can produce finished products and apply them in a short time
.
Use 3D printing technology to prepare compound preparations to prevent patients from missing medications
.
3D printing technology can be used to produce low-stability drugs, and immediate production and consumption can prevent the active ingredients of the drug from degrading due to environmental changes and reducing efficacy
.
The use of 3D printing technology to produce medicines can realize the on-demand preparation of medicines, which is expected to reduce medicine inventory and solve the storage problem of medicines
.
Easy to expand production: 3DP technology has simple operation, fast speed, good process repeatability, and easy industrialization
.
The process parameters and system parameters in the preparation process are saved by the computer, and when the industrialization is scaled up, mass production can be performed according to the original saved data
.
This simplifies and speeds up the transformation process from drug development to production, while reducing batch-to-batch variation
.
In recent years, instant drug delivery systems are gradually becoming the main direction of medical research at home and abroad, as well as one of the hotspots of pharmaceutics research
.
With the increase in clinical demand for instant drug delivery systems and the continuous improvement of drug safety and effectiveness requirements, the unique advantages of new instant technologies such as freeze-drying technology and 3D printing technology in formulation research have led to numerous studies Wide attention from personnel and pharmaceutical companies
.
These new fast-dissolving technologies can avoid the shortcomings of traditional formulation technology to a certain extent, endow the fast-dissolving formulations with new characteristics, and provide new ideas and strategies for the development of new-type fast-dissolving formulations
.
references:
[1]Ju Xiaoli, He Jun, Yang Yani, Bian Wei, Ni Meiping.
Application of new instant technology in the study of immediate release preparations[J].
Chinese Journal of Pharmaceuticals, 2017, 48(03): 434-441.
[2] Wang Senyi, Li Sijia, Tu Yingying, Li Linghui, Jiang Shuguang.
Application and challenges of 3D printing technology in oral solid preparations[J].
Chinese Journal of New Drugs, 2020, 29(08): 881-889.
[3]Shi Jing, Wang Zengming, Zheng Aiping.
Application and challenges of 3D printing technology in pharmaceutical preparations[J].
Progress in Pharmaceutical Sciences, 2019, 43(03): 164-173.
About the author: Sha Luo, a Chinese medicine research and development worker, currently works for a large domestic drug research and development company, and is committed to the research and development of new Chinese medicines
.
All rights reserved, no reprint without permission
.