Application of modern extraction and separation technology of traditional Chinese medicine in health wine

Abstract: the chemical composition of traditional Chinese medicine is very complex, which contains many kinds of effective components It is an important content in the research field of traditional Chinese medicine to extract the effective components and further separate and purify them In recent years, China has introduced many new technologies and methods in the extraction and separation of effective components of traditional Chinese medicine, and some new developed extraction and separation technologies have obvious advantages in selectivity, work efficiency, energy saving and environmental protection, showing excellent application prospects In the extraction and separation of effective substances (monomer, effective parts, effective components, etc.) of traditional Chinese medicine, it is often difficult to achieve the goal by using one technology, and the use of a single technology is difficult to apply to all extraction and separation objects The research level and quality assurance of traditional Chinese medicine depend on the results of extraction and separation of effective components to a great extent In order to improve the quality of traditional Chinese medicine, change the "big, black and thick" state of traditional Chinese medicine dosage forms, and let traditional Chinese medicine enter the international market, some modern high-tech engineering technologies are constantly being used for reference in the production of traditional Chinese medicine On the one hand, the production of traditional Chinese medicine is more in line with the traditional Chinese medicine theory, to ensure the quality requirements of medicine, on the other hand, it also improves the utilization rate of existing Chinese herbal medicine resources Traditional Chinese medicine research is also divided into single medicine research and compound medicine research The modern separation and analysis method is only to complete some classic small prescriptions, which are composed of two or three kinds of medicine There are dozens to dozens of ingredients in a medicinal material, let alone large prescriptions with more than ten herbs Therefore, it is very difficult to complete the research work thoroughly In this case, the research of single drug is an effective means to guide the discovery First of all, we should know what kind of substance the leader has, so that we can study the content of each chemical component, the production of new substances and so on After years of efforts, the technical center of Jinpai Co., Ltd has made in-depth research on the main raw materials of Chinese traditional medicine for health wine mainly composed of Jinjiu, and has developed a series of modern extraction and separation processes for effective substances The traditional Chinese medicine extraction technology now applied by Jinpai Co., Ltd not only embodies the classic traditional technology, but also applies a large number of new extraction and separation technologies and new methods, as well as integrated optimization technology, which is the inheritance and development of traditional Chinese medicine The traditional methods of extraction and separation of traditional Chinese medicine include decoction, immersion, percolation, modified gelatin, reflux, etc., among which decoction is the most commonly used method There are many disadvantages in the traditional method: there are many losses of effective components, especially water-insoluble components in the decocting method; the organic solvent may interact with the effective components in the extraction process, making them lose their original effectiveness; the non effective components cannot be removed to the maximum extent, and the concentration rate is not high enough; In addition to the effective components in the extraction solution, there are often many impurities and a small amount of fat soluble components, which brings disadvantages to refining; high temperature operation will cause a large number of decomposition of the heat sensitive effective components A new method of extracting effective components of traditional Chinese Medicine In recent years, many new technologies and methods have emerged in the extraction and separation of traditional Chinese medicine, such as supercritical fluid extraction, ultrasonic extraction, ultra-high pressure extraction, semi bionic extraction, high-speed centrifugal separation, macroporous resin adsorption separation, inorganic membrane microfiltration, ultrafiltration membrane separation, nanofiltration membrane concentration technology, etc The application of these new technologies and methods makes the extraction of traditional Chinese medicine not only conform to the traditional theory of traditional Chinese medicine, but also achieve the purpose of improving the yield and purity of effective ingredients Therefore, the application of new extraction technology to study traditional Chinese medicine is an important way to realize the modernization of traditional Chinese medicine The application of extraction and separation technology of traditional Chinese medicine the production technology of health care products of traditional Chinese medicine involves extraction, separation technology, online detection of labeled components, quantitative ingredients of labeled functional components of traditional Chinese medicine, flavor blending, aging treatment, filtration and clarification, etc Jinpai company adopts advanced domestic production equipment and process in the second stage extraction and separation workshop, and the process flow designed by the company is at the leading level in China at present 1 Single drug extraction (1) can effectively control the fluctuation of the quality of medicinal materials; (2) can avoid the uniformity difference of the quality of finished products caused by the difference of the content of medicinal materials transferred to China Wine News Network; (3) can meet the personalized requirements of different extraction parameters of medicinal materials and improve the extraction and transfer rate of medicinal materials; (4) it can effectively utilize the resources of medicinal materials and expand the comprehensive utilization and secondary extraction of medicinal materials 2 Dynamic countercurrent extraction (1) the countercurrent extraction process can be applied to the extraction of various batches of medicinal materials through the formation of concentration gradient According to the amount of medicinal materials, the combination of 3 to 8 tanks can be used for dynamic countercurrent extraction; (2) the solvent used in the countercurrent extraction process of the dynamic group tank is 2 / 5 of the hot reflux, which greatly saves the extraction solvent and reduces the energy consumption required for the treatment and concentration of the later extraction solution; (3) the extraction temperature is 50 ℃ to 65 ℃, which can save energy and reduce the damage of the easily oxidized components of the medicinal materials; (4) the transfer rate of the countercurrent extraction technology of dynamic pot group is 5% to 15% higher than that of the traditional hot reflux extraction technology, which improves the utilization rate of the medicinal materials 3 Supercritical fluid extraction (SFE) technology is adopted by Jinpai company to extract the fragrant substances in the fragrant medicinal materials of Jinjiu, improve the purity of the fragrant substances, and make the fragrance of Jinjiu more natural and pure Solid liquid separation: Jingpai company adopts high-speed centrifugal technology for solid-liquid separation High speed centrifugation technology is a kind of method that the centrifugal acceleration is hundreds of times higher than the gravity acceleration through the high-speed operation of the centrifuge, so as to increase the settling speed and accelerate the precipitation and removal of impurities in the liquid medicine It is more suitable to separate the suspension of fine particles or floccules which are difficult to settle and filter Jinpai company uses the disc centrifuge of Alfa Laval, Switzerland, to clean the extracted solution After the disc high-speed centrifugation for solid-liquid separation, the extracted solution can remove the insoluble solids of more than 1 μ m in the extraction solution, laying the foundation for the next membrane treatment Ceramic membrane clarification treatment: after high-speed centrifugal separation, 0.05 μ m alumina sintered membrane is used for fine filtration to remove insoluble particles with diameter greater than 0.05 μ m in the solution Through high-speed centrifugation and ceramic membrane treatment, the extraction solution of traditional Chinese medicine has replaced the traditional alcohol precipitation process, and the component transfer rate of this process is more than 20% higher than the traditional alcohol precipitation process, reaching about 95% Therefore, it innovatively replaces the alcohol precipitation process of traditional Chinese medicine extraction, greatly improves the utilization rate of traditional Chinese medicine, and reduces the loss of functional components Ultrafiltration membrane molecular separation: the ultrafiltration is driven by pressure According to the size and properties of molecules in the system, it can separate substances with molecular weight of 1000-1000000 daltons through the screening function of membrane at the molecular level According to the molecular weight and the three-dimensional structure of the functional components of the medicinal materials, Jinpai company uses 10000-50000 Dalton molecular weight organic membrane to separate the large molecules (more than 50000) and non functional components in the extraction solution, and retains the low molecular weight chemical functional components and the substances below 50000 molecular weight, so as to make the polysaccharides, total flavonoids, total glycosides and alkaloids in the extraction solution The retention rate of the same components was over 95%, which made the functional components of the medicine further separated and purified Nanofiltration membrane concentration process: Jinpai company uses nanofiltration membrane to cold concentrate the treated extraction solution, separate the water and alcohol in the extraction solution, and return the separated solvent to recycling It is used to concentrate the extracted solution after separation, and the concentration ratio is about 10 to 15 times Nanofiltration concentration has the advantages of low temperature, fast time, low loss, and can reduce the damage of heat exchanger to functional components in traditional heat concentration Quantitative allocation of labeled functional ingredients: the near-infrared online detection equipment is used to establish the near-infrared model of different ingredients, and online detection of functional ingredients is carried out for the concentrated solution of medicinal materials According to the proportion of ingredients and the content of labeled ingredients, the single drug extract is automatically proportioned and mixed by computer software, and then sent to the health wine allocation system for allocation, so as to ensure the average quality of products Consistency, so that the content of the functional components of the product is within the allowable fluctuation range of the process.