Antitumor effect of extracts from Juglans mandshurica
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Last Update: 2014-01-02
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Source: Internet
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Author: User
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Recently, researchers from the school of life science and biopharmaceutical science, Shenyang Pharmaceutical University (Shenyang Pharmaceutical University) proposed to study the antitumor activity of SH, an extract of Juglans mandshurica, in vitro and in vivo The results showed that sh from Juglans mandshurica could inhibit the proliferation of HeLa and Hca-F tumor cells in vitro and the growth of S180 sarcoma in vivo, suggesting that sh from Juglans mandshurica had certain antitumor activity This paper was published in the 10th issue of Journal of Shenyang Pharmaceutical University in 2013 In vitro, the inhibitory effect of SH on the proliferation of human cervical cancer cell line HeLa and mouse ascites hepatoma cell line Hca-F was detected by MTT method; in vivo, the S180 solid tumor model of mice was used to evaluate the SH and KL contents (4.5, 9.0, 18.0 Mg · kg-1) and its combination with cyclophosphamide (CTX) can inhibit the growth of S180 sarcoma In vitro experiments showed that sh could significantly inhibit the proliferation of HeLa and Hca-F tumor cells; in vivo experiments showed that sh had a significant antitumor effect, the antitumor rates of medium and high dose groups (9, 18 mg · kg-1) were 25.9% and 35.3%, respectively When combined with CTX, the antitumor rate of CTX was increased, and the antitumor effects of medium and high dose groups (9 + 10 mg · kg-1, 18 + 10 mg · kg-1) were additive.
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