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    Home > Food News > Food Articles > Antioxidative and anti-inflammatory effects of FSHW tea polyphenols in inflammatory bowel disease

    Antioxidative and anti-inflammatory effects of FSHW tea polyphenols in inflammatory bowel disease

    • Last Update: 2022-05-08
    • Source: Internet
    • Author: User
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    Introduction

    Primary metabolites such as carbohydrates, amino acids, and fatty acids, which are widely present in animal and plant cells, are essential for cell structure and basic metabolism


    Tea ( Camellia sinensis ), the second most consumed beverage in China for thousands of years, can generally be divided into three main categories (green tea, oolong tea, and black tea), which differ in their production methods and chemical composition


    Compared to oolong or black tea, green tea is much higher in polyphenols because the tea leaves are processed through different methods after they are harvested


    Tea also contains small amounts of flavonols, mainly myricetin, quercetin, kaempferol and their glycosides


    Recent studies have shown that polyphenols have antioxidant and anti-inflammatory properties, which can be beneficial to health and help treat inflammation-related diseases


    Figure 1 Structure of major tea polyphenols and their roles in the management of inflammatory bowel disease


    Tea polyphenols have been reported to have antioxidant and anti-inflammatory properties that aid in the treatment of IBD


    Effects of tea polyphenols on inflammatory response in IBD

    In addition to the inhibition of NF-κB, AP1 and STAT transcription factors and leukocyte and T cell infiltration, activation of the cytoprotective system may contribute to the therapeutic benefit of tea polyphenols in colitis


    Figure 2 Tea polyphenols inhibit colon inflammation by down-regulating inflammatory genes and up-regulating phase II antioxidant/detoxification genes

    Tea polyphenols and gut microbiota


    One study demonstrated that the fecal microbiota of green tea and black tea extract-treated donor mice was protective against DSS-induced colitis in mice by modulating microbiota composition


    Effects of tea polyphenols on intestinal barrier integrityTea polyphenols may have beneficial effects on IBD by improving epithelial barrier integrity


    The consumption of tea polyphenols is believed to have health benefits for the prevention and/or treatment of chronic diseases


    Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

    Van-Long Truong, Woo-Sik Jeong *

    Food and Bio-industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea

    *Corresponding author.


    E-mail address: wsjeong@knu.


    Abstract

    Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants.



    Reference:

    TRUONG VL, JEONG W S.
    Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases[J].
    Food Science and Human Wellness, 2022, 11(3): 502-511.
    DOI:10.
    1016/j.
    fshw.
    2021.
    12 .
    008.

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