Antimicrob Agents Ch: Good news! Two drugs are expected to fight COVID-19!

2020 May 15 News /BioValleyBIOON / - South Korean researchers screened 48 kinds of drugs FDA approved anti-SARS-CoV-2 found two of which have been FDA approved drug for other diseases seem promisingFDA approved the use of other drugs will greatly reduce the time a FDA approved a drug COVID-19The study, published in the Journal of the American Society for Microbiology "AntimicrobialAgentsandChemotherapy"researchers tested these drugs in Vero cellsVero cells are cultured kidney cells from African green monkeys out of a cell lineSource:NIAID co-author of the virus laboratory of the Pasteur Institute animal diseases Korea Seongnam SangeunJeon, MeehyunKo and their collaborators represent a niclosamide (niclosamide) named anthelmintic drugs have "very strong" antiviral activity against SARS-CoV-2They wrote: "Not surprisingly, broad spectrum antiviral which has been fully documented in the literature, including SARS and MERS-CoV antiviral properties." One drawbackniclosamide is absorptance low, due to a lower dose of the target tissue weakens the potency of the drugHowever, further development or pharmaceutical formulations may make this drug can be effectively delivered to the target tissueAlthough the antiviral efficacygreatly reduced, but the suctionfor treatment of asthma and allergic rhinitiscorticosteroid drugs Ciclesonide (Ciclesonide) also showed against SARS -CoV-2 promising Interestingly, the researchers noticed that a study published earlier this year on the three infected SARS-CoV-2 treatment of patients report shows the antiviral activity of the drug, and reveals the molecular target of the drug It is a viral protein called Nsp15 of researchers concluded: "ciclesonide antiinflammatory activity has been demonstrated, it may be an effective medicament having antiviral and antiinflammatory dual role in the control of SARS-CoV-2 infection "Anti-inflammatory activity may play in inhibiting or preventing cytokine storm key role in cytokine storm is an immune inflammatory overreaction can result in patient death COVID-19 (Biovalley Bioon.com) reference:. TwodrugsshowpromiseagainstCOVID-19 SeungtaekKimetal IdentificationofantiviraldrugcandidatesagainstSARS-CoV-2fromFDA-approveddrugs AntimicrobialAgentsandChemotherapy (2020) .DOI: 10.1128 / AAC.00819-20