Antibody injections can fight COVID-19 infection

June 10, 2020 /PRNewswire/ --BiovalleyBIOON/- Antibodies are part of our bodyWe have billions of antibodies in our bodies, and their total weight is about 100 grams, or the weight of a bar of soapIf we have so many antibodies in our body, they must be safe and important, right?in fact, antibodies may be the safest treatment and have many important functionsOne of them is the protection and treatment of infections caused by virusesThe human immune system can produce antibodies against each virus that bind seiscombin to the virus and prevent viruses from infecting our cells -- so-called neutralizing antibodiesas an infectious disease scientist, Dimiter Stanchev Dimitrov is interested in antibody therapy, which is a relatively safe way to prevent serious diseases and save lives, especially when a new and deadly virus emergesPhoto Library: Steven McDowell Science Photo Library
Billions of people need antibodies to fight the new coronavirus in order to stop the spread of COVID-19So the question is, how do we (including research labs and pharmaceutical companies) isolate and produce enough neutralizing antibodies to meet everyone's needs? What areantibodies?our immune system produces antibodies to fight foreign pathogens, whether it'sbacteria
, viruses or fungiantibodies are Y-shaped blood proteins produced by white blood cells called "B cells" They neutralise pathogens by attaching to the surface of pathogens, preventing them from entering our cells and signaling our immune systems to remove pathogens from the body human body at any time there are a variety of antibodies in the flow, looking for foreign pathogens and attack When a particular virus, such as SARS-CoV-2, infects our body, our immune system tries to produce enough specific antibodies against it before the infection becomes unstoppable If we had antibodies against pathogens, the process would happen faster and be more successful in preventing infection look for antibodies to treat COVID-19
when Stanchev Dimitrov was in his native Bulgaria, he was fascinated by the so-called hybrid tumor technology and used it to produce monoclonal antibodies (mAbs), or an antibody known to be affinity for specific pathogens Later, at the National Institutes of Health, his team used a very powerful method called phage display and found highly specific and effective human monoclonal antibodies against many viruses, including SARS-CoV, MERS-CoV, Hendra and Nipa Now, at the University of Pittsburgh, his team has used phage to demonstrate the discovery of effective neutralizing monoclonal antibodies against SARS-CoV-2 They are now conducting animal experiments and expect their results to soon be published in a peer-reviewed magazine The most effective and secure monoclonal antibody sequence will be available to a company that will insert genes that encode antibodies into cells to produce large quantities of antibodies for human clinical trials there is also a way to extract B cells from patients who survive SARS-CoV-2 infection, select the cells that produce the most effective specific antibodies, and then culture them in a laboratory dish These lab-cultured B cells are then produced as small factories for neutralizing monoclonal antibodies A recent study published in the journal Science describes the work of Chinese scientists who identified two such antibodies in this way Chinese researchers in the SARS-CoV-2 infected animal model showed that these monoclonal antibodies are effective in blocking the virus A similar finding was reported in a paper published in the journal Cell using the same model image source: Cell
other published reports describe neutralizing SARS-CoV-2 monoclonal antibodies, but not evaluated in animal models Why are animal models so important ? Because there are many other factors that can affect the effectiveness of antibodies in living organisms that cannot be simulated in covered petri dishes For example, how long do monoclonal antibodies function in the body, and are they safe? Animal models can provide preliminary safety data In addition to animal models, a key mAb attribute to consider is whether it can be produced efficiently in a stable and safe form for human use based on the published studies mentioned above, media reports, generally good properties of antibodies, and Stanchev Dimitrov's experience, he believes that the relevant monoantibodies will be approved for SARS-CoV-2 prevention and treatment this year (BioValleyBioon.com) References: 1 Antibody injections fight coVID-19 infections - an an disease disease experts the sexplain
the 2Ju, B., Zhang, Q., Ge, J et al.
Human neutralizing antibodies elicited by SARS-CoV-2 infection Nature (2020) https://doi.org/10.1038/s41586-020-2380-z
3
A noncompeting pair of humans-sizing neutral anti-noncompeting pair of humans-neutral anti-noncompete-cnos co-de-19 virus binding to its-ringer ACE2 4
Potent Neutraling anti-bodies against SARS-CoV-2 Aire-Siu-
Siu