Antibacterial mechanism of "Golden tangerine peel" rich in MMA

"Sickness enters from the mouth" refers to bacteria that enter the human intestinal tract through the oral cavity and cause diseases.

Recently, Professor Chen Gu’s research group from the School of Food Science and Engineering of South China University of Technology published in the International Journal of Food Microbiology published in September entitled “Metabolomic insights into the inhibition mechanism of methyl N-methylanthranilate: A novel quorum sensing inhibitor and antibiofilm agent against Pseudomonas aeruginosa" research paper, reported for the first time the quorum sensing (QS) of N-methylaminobenzoate (MMA) in the dried tangerine peel against the food-borne pathogen Pseudomonas aeruginosa (also known as Pseudomonas aeruginosa) )'S inhibitory effect and mechanism

Research background and ideas

MMA did not inhibit the growth of Pseudomonas aeruginosa at a concentration of 1.

In summary, MMA effectively inhibits the quorum sensing of Pseudomonas aeruginosa, which is attributed to the interference of MMA with the key enzyme in the synthesis of the quorum sensing factor PQS, which leads to fatty acid accumulation, increased membrane permeability and a series of changes that ultimately weaken the Pseudomonas aeruginosa.

Innovation/application prospects

Corresponding author: Chen Gu

Chen Gu, professor, master/doctoral supervisor, received a master's degree and a doctorate degree from Sun Yat-sen University and Hong Kong University of Science and Technology in 1998 and 2004, respectively