Anti AI drugs extracted from corn can kill infected cells effectively

Chinese scientists obtained a protease mutant from corn that can selectively kill HIV infected cells, providing new ideas and strategies for the development of new anti HIV drugs This is the news from Kunming Institute of zoology, Chinese Academy of Sciences Yunnan Province, adjacent to Southeast Asian countries, was once a disaster area of drugs and AIDS in China Zheng Yongtang, a researcher at the Kunming Institute of zoology, Chinese Academy of Sciences, and Shao pengzhu, a professor at the Chinese University of Hong Kong, completed the research project, the source said Researcher Zheng Yongtang has been engaged in immunology, virology and anti HIV drugs for more than 20 years, especially in the research of anti HIV drugs, AIDS primate models, virus limiting factors, etc "HIV has a hidden mechanism, which can hide in cells for a long time and escape from the attack of the host immune system At present, the anti HIV drugs on the market can not selectively kill infected cells and eradicate the virus It is very important to study anti HIV drugs that selectively kill HIV infected cells and protect normal cells from harm," he said After years of cooperation, scientists from the mainland and Hong Kong have carried out a series of structural modifications and modifications on the internal inactivation domain of maize ribosome inactivation protein, and obtained a maize ribosome inactivation protein mutant that can recognize and activate HIV protease Cell level experiments show that the mutant has low toxicity to uninfected cells, but after entering HIV infected cells, the mutant can be recognized by the HIV protease in the cells, cut off the inactivated domain and transformed into active protein, so as to selectively kill HIV infected cells The results also showed that the mutant could enter the infected cells efficiently, so it had stronger killing power to the HIV-1 infected cells; the mutant could also be recognized and activated by the protease of the HIV protease resistant strains, so the mutant also had a good selective killing power to the HIV protease resistant strains Zheng Yongtang said that the research results provide new ideas and new strategies for the development of new anti HIV drugs specifically targeting HIV infected cells "The research results have been published in the international famous academic journal nuclear acids research and applied for national patent." Zheng disclosed that the research was supported by the Hong Kong research funding Bureau, the 973 project of the Ministry of science and technology of the people's Republic of China, the national major science and technology project, the Chinese Academy of Sciences and other projects.