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On February 21, Synairgen announced that the international Phase III SPRINTER clinical trial of SNG001 in hospitalized patients with new coronary pneumonia did not meet its primary or key secondary efficacy endpoints, but demonstrated a favorable safety profile and was well tolerated in this population
SNG001 is a naturally occurring broad-spectrum antiviral protein interferon beta that can be directly inhaled into the lungs to stimulate the body to produce an immune response
SPRINTER is a randomized, double-blind, placebo-controlled, international Phase III clinical trial designed to evaluate the efficacy and safety of SNG001 in the treatment of hospitalized patients with moderate COVID-19
The results showed that patients who received SNG001 were no more likely to be discharged from the hospital than those who received placebo
In terms of secondary endpoints, patients treated with SNG001 had a 27% and 36% lower relative risk of progression to serious disease or death within 35 days, respectively, compared to patients treated with placebo
Interestingly, in July 2020, Synairgen announced the phase I/II clinical data of SNG001.
(Original abridged)