Another 叒 in the Nature sub-issue! Four-stranded DNA structures have been found in breast cancer cells for the first time.

On April 25, 1953, two scientists, Francis Crick and James Watson of the University of Cambridge, wrote in Nature that they pioneered what is now known as a double helix DNA model, a discovery later known as the beginning of the era of molecular biology.
In 2013, researchers led by Shankar Balasubramanian, also from the University of Cambridge, published an article in the journal Nature Chemistry, using strong evidence for the first time that four-stranded DNA structures (G-four-stranded) do exist in living cells in the human body, and that these extraordinary structures may have important biological functions. the
G-tyrosome, which is a square formed by the interaction of four ostriches as the basis, is a transsogenic structure that is present in large numbers in the cells that are about to divide and appear in the nucleus of the chromosome and the end of the chromosome (which protects chromosomes from damage).
July 20, the Balasubramanian team published another paper in the journal Nature Chemistry.
the study created a fluorescent marker that can attach to the DNA G-tythchasin of living human cells, allowing researchers to observe for the first time how this particular DNA structure is formed and how it plays a role in gene transcription.
August 3, following the confirmation of the presence of G-tyrones in living cells and the observation of G-tyrones in living cells, the Shankar Balasubramanian team madenew discoveries.
they have shown for the first time that G-tychains in DNA play a vital role in specific types of breast cancer.
this finding offers promising new goals for personalized medicine.
findings were published in the journal Nature Genetics.
Balasubramanian said: "We are all familiar with the double-stranded, double-helix structure of DNA, but over the past decade it has become increasingly clear that DNA can also exist in four-stranded structures and that they play an important role in human biology.
they are particularly high in rapidly dividing cells, such as cancer cells.
new study is the first time we're found in breast cancer cells.
" specifically, due to inter-tumor and intum heteroglymology, anti-cancer therapy response and resistance are different.
to this end, the Balasubramanian team developed and used quantitative sequencing techniques to map the regions of DNA G-tyrion structure formation that are differently rich in tumor xenotagogic (PDTX) models from 22 breast cancer patients. G4Rs).
during cancer, during DNA replication and cell division, most areas of the genome may be mistakenly copied multiple times, leading to so-called copy number abnormalities (CNAs).
researchers found that G-tychains are common in these CNAs, especially in genes and genetic regions that play a vital role in titleting and driving tumor growth.
we often think of breast cancer as a disease, studies have found that there are at least 11 known substypes of breast cancer, each of which may respond differently to different drugs.
the study, the team found that each breast cancer subsysmone had a different G-tytse pattern.
to determine specific patterns of tumor G-tyts can help researchers identify subtypes of breast cancer in women, providing her with more personalized, targeted treatments.
In addition, the researchers identified two synthetic molecules that target G-tetrochaste, or pyridine and CX-5461, which can target G-tyrogens and may prevent cells from replicating their DNA and prevent cell division, thereby preventing out-of-control cell proliferation, the root cause of cancer.
summary, the study found that the abundance and location of G-4 chains reveal their importance in cancer biology and breast cancer heterogliity, as well as potential targets for fighting breast cancer.
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