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Innovent and Eli Lilly jointly announced the final clinical study results and biomarker analysis of Dabosu® (sintilimab injection) in combination with bevacizumab in the treatment of advanced hepatocellular carcinoma (NCT04072679) in Phase Ib (NCT04072679).
The study is a Phase Ib trial (NCT04072679) evaluating the safety, tolerability and antitumor activity in Chinese patients with locally advanced/metastatic hepatocellular carcinoma who have not or failed systemic therapy.
In terms of efficacy, the overall objective response rate (ORR) was 34% (17/50), with ORRs of 31% and 38% in the low-dose and high-dose groups, respectively