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On September 13, Harmonicare announced that its self-developed product HBM4003 has achieved positive results in a phase I dose-climbing clinical trial for patients with advanced solid tumors in Australia
The Phase I study data is the first clinical evidence of a new generation of anti-CTLA-4 fully human monoclonal heavy chain antibody (HCAb) in solid tumors
The Phase I study is an open-label, multi-center study conducted in subjects with advanced solid tumors.
Main results of the Phase I study
(I) The 4 Australian centers of the Phase I study enrolled 20 subjects with advanced solid tumors.
(Ii) HBM4003 therapy shows good safety
(Iii) It is recommended to use 0.
(Iv) A total of 15 patients underwent post-treatment tumor assessment
(V) For patients with hepatocellular carcinoma with partial remission, prolonged clinical benefit was observed after stopping treatment
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