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    Home > Medical News > Latest Medical News > Announcement of Phase I study of Hebo Pharma's new-generation anti-CTLA-4 antibody HBM4003

    Announcement of Phase I study of Hebo Pharma's new-generation anti-CTLA-4 antibody HBM4003

    • Last Update: 2021-10-23
    • Source: Internet
    • Author: User
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    On September 13, Harmonicare announced that its self-developed product HBM4003 has achieved positive results in a phase I dose-climbing clinical trial for patients with advanced solid tumors in Australia


    The Phase I study data is the first clinical evidence of a new generation of anti-CTLA-4 fully human monoclonal heavy chain antibody (HCAb) in solid tumors


    The Phase I study is an open-label, multi-center study conducted in subjects with advanced solid tumors.


    Main results of the Phase I study

    (I) The 4 Australian centers of the Phase I study enrolled 20 subjects with advanced solid tumors.


    (Ii) HBM4003 therapy shows good safety


    (Iii) It is recommended to use 0.


    (Iv) A total of 15 patients underwent post-treatment tumor assessment


    (V) For patients with hepatocellular carcinoma with partial remission, prolonged clinical benefit was observed after stopping treatment


    Note: The original text has been deleted

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