Ann Surg: Targeted muscle re-dominance treatment for neuromas and hallucinogenic pain in large limb amputees

The purpose of this study was to compare the effects of targeted muscle reneural control (TMR) on post-limb pain with neuroma removal and burial into the musclesTo date, no intervention has been effective on neuroma-related limbs or phantom limb pain (PLP)TMR is a neurometmetry developed to control the prosthesis, which can be found to improve post-prosthetic painwe conducted a prospective, randomized clinical trial that assigned 28 amputees with chronic pain to standard treatment or TMRThe main resultwas for preoperative and postoperative limb pain and PLP's numerical scoring table (NRS, 0-10) pain score changes after 1 yearSecondary results included NRS, PROMIS pain score, neuroma size, and patient function for all patients at the final follow-upThe results of theshowed that in the analysis of intentional treatment, the changes in the PLP score in TMR and the standard treatment year 1 years were 3.2 and -0.2 (difference of 3.4, the corrected confidence interval (acI)-0.1 to 6.9, and the corrected P-0.06)Residual limb pain score changes are 2.9 and 0.9 (difference 1.9, acI -0.5 to 4.4, P -0.15)In the vertical mixed model analysis, the difference in the change score of PLP in the TMR group was significantly greater than that of standard treatment (average (acI) s 3.5 (0.6, 6.3), P-0.03)Reduced residual limb pain is beneficial to TMR (P - 0.10)In the longest follow-up, including 3 cross-patients, the results were beneficial to TMR rather than standard treatmentin general, the results showed that tMR improved PLP and tended to improve limb pain in this first-time surgery for the treatment of post-amputation pain in large amputees