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    Home > Active Ingredient News > Antitumor Therapy > Ann Surg: Neoadjuvant radiotherapy VS. Surgical treatment for stage II/III rectal cancer with or without high-risk factors

    Ann Surg: Neoadjuvant radiotherapy VS. Surgical treatment for stage II/III rectal cancer with or without high-risk factors

    • Last Update: 2021-05-20
    • Source: Internet
    • Author: User
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    Neoadjuvant radiotherapy (NRT) is usually used for stage II/III rectal cancer to improve local control without affecting overall survival.


    According to the risk stratification criteria and clinical staging, eligible participants of stage II/III rectal cancer were included, preoperatively divided into patients with (high risk) or without (low risk) high-risk factors, and they were randomized to receive short-course radiotherapy (SCRT) ) + Total mesentery resection (TME) or TME alone, divided into the following 4 groups: high-risk patients receiving (HiR) or not receiving (HiS) radiation therapy, low-risk patients receiving (LoR) or not receiving (LoS) radiation therapy .


     

    A total of 401 patients were included in the final analysis.


    In summary, the results of the study indicate that stratifying stage II/III rectal cancer based on risk factors and making it a more precise sub-category may result in differences in survival rates and local recurrence control.


     

    Original source:

     

    Xiangbing Deng, et al.


    ncbi.
    nlm.
    nih.
    gov/31599809/" target="_blank" rel="noopener">Neoadjuvant Radiotherapy Versus Surgery Alone for Stage II / III Mid-low Rectal Cancer With or Without High-risk Factors: A Prospective Multicenter Stratified Randomized Trial in this message
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