Ann Rheum Dis: The efficacy and safety of hedonist mono-anti-subcutaneous administration to treat hip or knee osteoarthritis

In a study that included 24 weeks of treatment and 24 weeks of safe follow-up, the efficacy of neurogrowth factor inhibitors, tanyzumab, for the treatment of hip or knee osteoarthritis (OA) was analyzedthe double-blind, randomized, Phase III study recruited adult patients from Europe and Japan who were not responding to or tolerated standard therapeutic analgesicsThe patient was randomly divided into 2.5 mg or 5 mg or a matching placebo (3 doses) per 8 weeks of subcutaneous tattanylThe common primary endpoint was changes in pain and body function, as well as the overall assessment of oA in patients (PGA-OA), from the baseline to week 24 of Western Ontario and McMaster UniversityJoint safety and nervous system assessments continued throughout the 48-week studyfrom March 2016 to December 2017, 849 patients were randomly grouped and evaluated (placebo n?282, tanyzumab 2.5mg n-283, than-nizumab 5mg n-284)At week 24, compared to the placebo group, the WOMAC pain in the 5mg group of hennizumab (minimum two-component mean variance(-0.71 to 0.17, p 0.0001) and PGA-OA (-0.19 to 0.07, p-0.0051) with statistically significant improvements from baseline levelsFor the 2.5mg group, WOMAC pain and body function improved significantly, but the PGA-OA did not improvePatients with 2.5mg and nizumab 5mg had rapid progressive osteoarthritis (RPOA) in the 2.5mg group and the placebo group, respectively, with 1.4% (4/283) and 2.8% (8/284) without a placebo groupTotal joint replacement (TJRs) distribution was similar (6.7%-7.8%) in the three treatment groupsIt is more common to have abnormal sensations (5 mg) and retardation (both doses) in patients treated with than placebotanoinsed in 5mg significantly improved pain, body function and PGA-OA, but his Niedre 2.5mg resistance reached only two major finishesHis Nicomono resistance is 5mg more frequently than his Nizumab mono-resistance 2.5mg of RPOAThe distribution of the three groups of TJRs is similar