Ann Rheum Dis: Lupus nephritis 1 year lack of EULAR/ERA-EDTA response can predict long-term kidney prognosis

Lupusnene nephritis (LN) requires a short-term predicted end point for chronic kidney disease (CKD)The study analyzed the treatment response over a yearThe study analyzed LN patients who underwent induced treatment after receiving a renal biopsy from January 1970 to December 2016LN's assessment uses the International Society of Nephrology/Nephrology Society (2003) standard and the National Institutes of Health (NIH) activity and chronic indexThe kidney sesame is CKDDefined response according to eULAR/European Union against Rheumatism Union/European Kidney Association-European Dialysis and Transplantation Association (EULAR/ERA-EDTA) guidelines: Full response: proteinuria 0.5g/24 hours, (close) normal estimated renal glomerular filtration rate (eGFR); Use Logistic regression to analyze responses for 12 months and use Cox regression to predict CKDA total of 381 patients (90.5% caucasian) were studiedAfter 12 months of treatment, 58%, 26%, and 16% of patients achieved full, partial and no response, according to EULAR/ERA-EDTADuring a median follow-up period of 10.7 years (IQR: 4.97-18.80), 53 patients developed CKDAt the 15th year, the non-CKD survival rates were 95.2%, 87.6% and 55.4% (p 0.0001) for patients with complete response, partial response and non-answer, respectively, in 12 monthsThere was no difference in CKD-free survival rates for full and partially answered patients (p-0.067)At 12 months, hemoglobinin (HR:1.485, 95% CI 1.276-1.625), eGFR (HR 0.967, 95% CI 0.957-0.977) and proteinuria (HR 1.234, 95% CI 1.111-1.379) are related to CKD, but there are no reliable thresholds for the subject's working characteristicsIn multi-factor analysis, no EULAR/ERA-EDTA response at 12 months (HR 5.165, 95% CI 2.770-7.628), low C4 (1.053, 95% CI 1.019-1.089) and continuous arterial high pressure (HR 3.154, 95% CI 1.500-4.574) can be predicted independentlyThe lack of an EULAR/ERA-EDTA response at 12 months can predict CKD