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Ann Oncol: Pembrolizumab has a solid effect in locally advanced/recurrent/metastatic squamous cell carcinoma of the skin!

 Last Update: 2021-07-27
 Source: Internet
 Author: User

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Pembrolizumab (MK-3475, trade name Keytruda) is a humanized anti-PD1 monoclonal antibody
.

Pembrolizumab has shown clinically significant and durable anti-tumor activity in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC), and its safety is controllable

KEYNOTE-629 is a global, open-label, non-randomized Phase 2 trial that recruited locally advanced (LA) or R/M cSCC patients in 59 medical centers
.

The test patients were given intravenous pembrolizumab 200 mg/3 weeks for up to 35 courses

Remission of the two cohorts

From November 29, 2017 to September 25, 2019, a total of 159 patients were recruited to receive pembrolizumab treatment (LA cohort, n=54; R/M cohort, n=105)
.

The median time from the first dose to the data cut-off date of the LA cohort and R/M cohort were 14.

In the LA cohort, the ORR was 50.

Pembrolizumab has proven its strong anti-tumor activity in patients with locally advanced and recurrent or metastatic squamous cell carcinoma of the skin, and has a long-lasting effect Pembrolizumab in locally advanced and recurrent or metastatic squamous cell carcinoma of the skin The strong anti-tumor activity in patients has been proven, and the effect is long-lasting

Original source:

Hughes BGM,Munoz-Couselo E,Mortier L et al.

Pembrolizumab for locally advanced and recurrent / metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial in this message

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