Ann Neurol: Some new crown vaccines have the risk of causing encephalitis, but... it is still recommended to be vaccinated

The global novel coronavirus epidemic has led to more than 163 million confirmed infections and 3.
3 million deaths worldwide
.

At present, many effective vaccines have been approved due to their good safety and data validity in clinical trials

The global novel coronavirus epidemic has led to more than 163 million confirmed infections and 3.

At present, the local and systemic side effects of ChAdOx1 nCoV-19 vaccine do not have important clinical relevance, but recently there have been more and more reports of autoimmunity- induced thrombocytopenia and subsequent thrombosis

Frédéric Zuhorn of Bielefeld University in Germany and others reported a series of cases of post-vaccine encephalitis related to the time of ChAdOx1 nCoV-19 vaccination

The reported case is characterized by symptoms of encephalitis within 7 to 11 days after vaccination with ChAdOx1 nCoV-19 vaccine
.

In all three cases, autoimmune encephalitis was diagnosed and immunosuppressive therapy was initiated

The reported case is characterized by symptoms of encephalitis within 7 to 11 days after vaccination with ChAdOx1 nCoV-19 vaccine

After excluding encephalitis caused by pathogens, 2 out of 3 patients received immunosuppressive therapy, and the clinical improvement was rapid

Generally speaking, vaccination can cause strong expression of pro-inflammatory cytokines and T cell response

In fact, the occurrence of encephalitis after vaccination has been reported before.
In a survey conducted in the United States for more than 20 years, 141,396 cases of encephalitis occurred after vaccination

Several public databases have reported the occurrence of encephalitis after vaccination with ChAdOx1 nCoV-19 (AZD1222) vaccine

After vaccination with ChAdOx1 nCoV-19 vaccine, 79 cases of encephalitis were
found worldwide .

It is estimated that the incidence rate is about 8 cases per 10 million doses of vaccine

After vaccination with ChAdOx1 nCoV-19 vaccine, 79 cases of encephalitis were

Inoculated ChAdOx1 nCov-19 after the vaccine cases of accumulation and vaccination Pfizer - Biotechnology mRNA cases after the vaccine has accumulated a significant difference (ChAdOx1 nCov-19: 79 cases, 9930 Wan Ji ; Pfizer Pfizer - Biotechnology mRNA vaccine : 1.

Obviously, encephalitis after ChAdOx1 nCoV-19 vaccination is still very rare, but adequate diagnosis and treatment are needed, and the benefits of vaccination outweigh the risks
.
Encephalitis after ChAdOx1 nCoV-19 vaccination is still very rare, but adequate diagnosis and treatment are required, and the benefits of vaccination outweigh the risks
.
The large amount of data collected from observational epidemiological studies is necessary to verify causality
.

Original source

Zuhorn F, Graf T, Klingebiel R, Schäbitz WR, Rogalewski A.
Postvaccinal encephalitis after ChAdOx1 nCov-19 [published online ahead of print, 2021 Jul 29].
Ann Neurol.
2021;10.
1002/ana.
26182.
doi:10.
1002/ana .
26182

Zuhorn F, Graf T, Klingebiel R, Schäbitz WR, Rogalewski A.
Postvaccinal encephalitis after ChAdOx1 nCov-19 [published online ahead of print, 2021 Jul 29].
Ann Neurol.
2021;10.
1002/ana.
26182.
doi:10.
1002/ana .
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