Ann Hematol: Primary Central Nervous System Lymphoma in China

Primary central nervous systemlymphoma(PCNSL) is a rare form of ligand-type non-Hodgkin lymphoma, and a few cases have been reported in ChinaThe study was designed to investigate the clinical pathological characteristics of thePCNSL from a single centre in East Chinaand to identify potential prognosis factors for overall survival rate (OS) and non-progression survival rate (PFS)we recruited all continuous PCNSL patients who received histopathological diagnosis at our centre sourcing between January 2003 and October 2017Collect demographic and clinical pathology data and review themUse the dating rank test and Cox regression analysis to identify the potential risk factors for OS and PFSresults, a total of 167 cases withimmunefunction were selectedThe median age is 58 years (range 17-96 years old), with a ratio of 3:2 for men and womenHeadaches (n s 65; 39%) and the brain (n s 96; 57%) are the most common complaints and pain areas, respectivelyOf the 167 cases, 150 were diffuse large B-cell lymphomasMedian follow-up time is 25 months (range 1-152), median OS?? and PFS for 37 months (95% CI, 25-49) and 17 months (95% CI, 13-20), respectivelyPostoperative residual tumors, chemotherapy without HD-MTX, and palliative care were considered independent prognostic indicatorsIn addition, ECOG 3, polylesionsis and palliative care are considered independent prognosis indicators of PFS disadvantagein general, Chinese PCNSL patients have distinct characteristicsFurther research is needed to confirm the prognostic value of these factors and to optimize treatment for these patients