Animal studies have shown that anti-cancer drugs can treat autism social defects
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Last Update: 2020-12-17
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Source: Internet
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Author: User
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U.S. scientists have found through animal experiments that the cancer drug Lamedesin can restore a group of brain-related genes to normal operation and alleviate social behavioral deficiencies in autistic laboratory mice.
Xinling University of New York at Buffalo researchers say the new study, which looked at mice with autism due to the Shank 3 gene defect, used low-dose roxycin for three days and found that improving social behavior lasted about three weeks, the equivalent of several years in humans.
the team has previously found that the Shank 3 gene is an important autism risk gene, a defect that causes histoprotein deacetylase 2 to be too high and incorrectly inhibits a number of genes associated with nerve signaling in the brain. These genes themselves do not mutate, but are unable to function properly due to upstream regulatory failure, leading to autism behavior.
is itself a hiprotein deacetylase inhibitor used to treat certain T-cell lymphomas. It prevents histogen deacetylase from functioning, freeing the gene from binding and allowing it to return to normal expression.
new study shows that drugs that adjust the expression of multiple genes to relieve autism symptoms are a promising treatment, but the effects on humans need to be tested. The paper is published in a new issue of
Journal. (Source: Xinhua News Agency)
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