Angelw Chem: after more than half a century of trying, scientists have finally successfully realized the key components of synthetic poisonous mushroom!

August 18, 2017 / BIOON / -- recently, researchers from Friedrich Schiller University found a way to synthesize psilocybin In a recent article published in the Journal Angewandte Chemie, the authors described the means of separating and synthesizing the enzyme, the corresponding materials and methods, and the final sample of celecoxib For thousands of years, people have known that they will have hallucinations after eating some magic mushrooms However, it is known that in 1958, Albert Hofman first isolated the active component, namely, the optically active celecoxib However, due to the difficulty of artificial cultivation, the separation efficiency is low As a result, the commercial value of sailosibin cannot be realized Therefore, researchers have been trying to find a synthetic method of celecoxib (photo source: CCO public domain) in order to study how some types of mushrooms synthesize celecoxib under natural conditions, the researchers sequenced two main types of poisonous mushrooms and isolated the related factors of the enzyme responsible for the synthesis of celecoxib Next, they verified the previous findings and studied the specific steps of the synthesis of celecoxib by culturing engineered fungal and bacterial samples The results showed that there were four enzymes involved in the synthesis of celecoxib, and further study found that only three of them (PSID, psik, PSIM) were necessary for the laboratory synthesis Using the above information, the researchers developed a reaction system called "one pot" Using the enzyme isolated before, they finally successfully realized the synthetic synthesis of seloxibine This breakthrough has opened the door to the commercial application of celecoxib, which may have the effect of treating mental illness and drug addiction Source of information: after a half century of attempts, psilocybin has finally been synthesized in the lab original source: Janis Fricke et al