Angelica extract has significant therapeutic effect on hypertension

About 80% of the patients with hypertension are accompanied by the increase of blood lipid and viscosity, which is easy to induce coronary heart disease How to reduce blood fat and blood viscosity while reducing blood pressure, without the side effects caused by western medicine? After more than 20 years of research, researchers of traditional Chinese medicine have found that angelica extract has significant therapeutic effect on hypertension, which is a common disease According to statistics, at present, there are 160 million patients with hypertension in China, and it is estimated that it will reach 400 million in 2025 Among them, about 80% of them are associated with the increase of blood lipid and viscosity, which is easy to induce coronary heart disease Recently, a research achievement lasting for more than 20 years will benefit a large number of hypertensive patients Angelica extract can not only significantly reduce blood pressure, but also reduce blood viscosity and regulate immune function Its efficacy and safety are better than nifedipine The project "mechanism and clinical research of angelica extract in the treatment of hypertension" was led by Professor Lv Guiyuan of Zhejiang University of traditional Chinese medicine, and recently won the second prize of national science and technology progress "For more than 20 years, we have been looking for an ideal antihypertensive drug." Lu Guiyuan said that patients with high blood pressure need early and lifelong medication, but there is still a lack of long-term safe drugs Although chemical drugs have strong antihypertensive effect, they are prone to joint swelling, sexual dysfunction and other adverse reactions After screening more than 30 kinds of traditional Chinese medicine, researchers found that Angelica contains a new blood pressure reducing component, which can work together with other components of Angelica to reduce blood pressure Hypertension is a chronic disease of middle-aged and old people, which often presents hypercoagulable state due to long illness or old blood, showing signs of "deficiency and blood stasis" in different degrees The clinical manifestations are dizziness, dizziness, headache, tinnitus, insomnia, forgetfulness and other deficiency syndrome According to Lu Guiyuan, according to the theory of traditional Chinese medicine, the organs involved in hypertension are liver, spleen and kidney, which are closely related to "blood", while many patients with hypertension coexist with "deficiency" and "stasis" Angelica can nourish deficiency and move blood stasis, and has a significant effect on essential hypertension with Yin deficiency and yang hyperactivity and blood stasis The original cause of hypertension is due to the imbalance of blood supply and demand Angelica has the effect of invigorating blood and activating blood circulation It can improve the balance of blood supply and demand through the way of invigorating deficiency and removing blood stasis, so as to treat hypertension For the first time, this topic puts forward a new opinion of "seeking the essence and regulating blood" in the treatment of hypertension, which enriches the theory of traditional Chinese medicine in the treatment of hypertension Lu Guiyuan and others carried out systematic research on the quality and pretreatment of medicinal materials, depressor and pressor substances, pressor substances removal and extraction of effective substances, efficacy and toxicology, effective substances and content, pharmacokinetics and blood drug spectrum effect correlation, found pressor substances, established removal technology and corresponding parameters, found and identified process quality control substances, and established the best process And its parameters, revealed the antihypertensive components and mechanism of action, established the fingerprint of Angelica sinensis - intermediates - preparations, clarified the pharmacokinetic and serum component spectrum - pharmacodynamic relationship It was found that angelica extract has significant antihypertensive effect, and can accelerate microcirculation, reduce blood viscosity, diuresis, regulate blood lipid and immunity These effects are beneficial to reduce blood pressure, heart disease and other complications They can reduce blood pressure through the comprehensive effects of receptor, channel, renin-angiotension activity, lipid and viscosity Further study confirmed that its antihypertensive components are tannic acid, adenosine, taurine and ferulic acid, etc., and put forward a new view of "mechanism combined with efficacy to comprehensively elaborate the mechanism of action of traditional Chinese medicine", which provides a theoretical basis for fully showing the advantages and potential of traditional Chinese medicine in the treatment of hypertension, and puts forward a new idea of developing high-efficiency characteristic traditional Chinese medicine According to the double blind randomized controlled study of 400 patients with stage II hypertension in Xiyuan Hospital of Chinese Academy of traditional Chinese medicine, the total effective rate of angelica extract is 74%, the syndrome effective rate is 82%, which is similar to or superior to nifedipine, and there is no adverse reaction, and it can reduce blood viscosity, regulate blood lipid and immunity These effects are beneficial to control blood pressure, reduce complications, show the characteristics of traditional Chinese medicine, long-term efficacy and safety advantages, will benefit a large number of patients with hypertension, and vigorously promote the development of traditional Chinese medicine industry At present, the project has obtained new drug certificate, production approval and patent certificate According to experts such as Wang Yongyan, Hu Zhibi and Zhang Boli, academicians of the Chinese Academy of engineering, the project is innovative in TCM theory, leading in China or advanced in the world as a whole, and a model for the modernization of TCM research Expert evaluation - Academician Wang Yongyan: This study shows the characteristics of the multi-component comprehensive effect of traditional Chinese medicine, the long-term effect trend and safety advantages of treating hypertension The theoretical research of traditional Chinese medicine of the project has innovative ideas, basically conforms to the requirements of international natural medicine research, and belongs to the domestic leading and partial international advanced level in the research of traditional Chinese medicine antihypertensive system It is suggested to open up the market as soon as possible and promote the application Academician Hu Zhibi: the project is reasonable in design, advanced in method, in-depth in research system and theoretical research innovation of traditional Chinese medicine It basically meets the requirements of international natural medicine research It is a leading domestic and international advanced level in the research of antihypertensive system of traditional Chinese medicine and a model of modern research of traditional Chinese medicine It is suggested to open up the market as soon as possible to meet the treatment needs of hundreds of millions of patients with hypertension Academician Zhang Boli: the research of the project is innovative in theory, the methods adopted are advanced and standardized, the research results have been transformed, the comprehensive benefits are outstanding, and the overall research has reached the leading level in China It is suggested to open up the market as soon as possible and promote the application.