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Illustration: An aneurysm is a weak point in the wall of a vein that can cause blood vessels to swell and rupture
.
Image source: Terasaki Institute for Biomedical Innovation
Aneurysms are weak points in the walls of veins that require immediate attention, as they can cause blood vessels to swell and rupture
.
Existing treatments include placing platinum or stainless steel coils, but this requires specialized catheters and equipment to place and separate them, which can also be moved elsewhere within the blood vessels
.
A collaborative team of scientists from the Terasaki Institute for Biomedical Innovation (TIBI) has developed an injectable shear dilution hydrogel (STH) that has enhanced cohesion strength and resists rupture
even when subjected to a strong pulsating flow of fluid in the body.
The research team first added nanoparticles to the gel-based STH to enhance their shear thinning ability, mechanical stiffness and physiological stability
.
During the process of testing STH-filled containers under constant and pulsating buffered streams for up to 4 days, the researchers were able to observe and quantify the retention of STH blockages
.
Further tests showed that STH did not cause cell damage or erythrolysis, proving that it is safe
for the treatment of vascular disease.
Dr Ali Khademhosseini, Director and CEO of TIBI, said: "This improved shear thinning hydrogel can withstand real body pulsation streams and has made significant progress
in treating severe vascular diseases.
