Andrographolide can inhibit intimal hyperplasia of vein graft

An extract of Andrographis paniculata, a traditional Chinese medicine, can inhibit intimal hyperplasia of vein grafts at the transcription level Professor Liu Hongyu, director of cardiovascular surgery of the First Affiliated Hospital of Harbin Medical University, led the research paper "the effect of andrographolide on the intimal hyperplasia of vein autograft in rats", which was published in the latest issue of American Journal of cell biochemistry and biophysics Some studies have shown that a certain dose of Andrographis paniculata total flavonoids can significantly improve epicardial ECG in dogs with experimental coronary thrombotic myocardial infarction Inspired by this, Liu Hongyu group established a rat model of vein autotransplantation Two days before the operation, andrographolide was administered to the stomach, while the control group was administered to the stomach with normal saline The ratio of neointima area to mesomembrane area, the expression of protein factor p65, E-selectin, matrix metalloproteinase-9 protein and mRNA were observed In addition, the contralateral external jugular vein was taken as the normal vein for comparison The results showed that intimal hyperplasia appeared in the grafted vein after the autogenous vein was transplanted to the artery Compared with the control group, andrographolide in the experimental group significantly inhibited endometrial hyperplasia Further study showed that andrographolide could effectively inhibit the expression of nuclear transcription factor kappa B, p65 protein and messenger RNA, and significantly inhibit the expression of E-selectin and matrix metalloproteinase-9 protein The mechanism of inhibiting intimal hyperplasia of vein grafts is to inhibit the expression of E-selectin, matrix metalloproteinase-9 protein and messenger RNA through kappa B signal pathway Restenosis of "vascular bridge" after CABG has always been the main problem affecting the long-term effect Andrographolide can inhibit the proliferation of vein intima, which is expected to reduce the restenosis rate of "vascular bridge" after bypass.