Analyze the key figures of the 2020 National Adverse Drug Reaction Monitoring Annual Report

4) Patients aged 15-44 accounted for 26.
6%, a slight increase compared with 2019 (26.
5%);

5) Patients aged 5-14 accounted for 3.
1%, a slight decrease compared with 2019 (4.
4%);

6) Patients aged 1-4 accounted for 3.
2%, a slight decrease compared with 2019 (3.
3%);

7) Patients younger than 1 year old accounted for 1.
4%, a slight decrease compared with 2019 (2.
5%), as shown in the figure below:

Fifth, the adverse drug reaction/event report involves the category of drugs

In the 2020 adverse drug reaction/event report, according to the category of suspected drugs, chemical drugs accounted for 83.
0%, a slight decrease compared with 2019 (84.
9%); Chinese medicine accounted for 13.
4%, compared with 2019 (12.
7%) , A slight increase; biological products accounted for 1.
1%, a slight decrease compared with 2019 (1.
6%); unclassified accounted for 2.
5%, compared with 2019 (0.
8%), a slight increase, as shown in the figure below:

6.
Adverse drug reaction/event reports related to the route of administration

In the 2020 adverse drug reaction/event report, according to the route of administration, injection administration accounted for 56.
7%, a slight decrease compared with 2019 (62.
8%); oral administration accounted for 38.
1%, compared with 2019 (32.
5%) ) Compared with a slight increase; other routes of administration accounted for 5.
2%, a slight increase compared with 2019 (4.
7%)
.
In injection administration, intravenous administration accounted for 91.
1%, which was a slight decrease compared with 2019 (92.
5%); other injection administration accounted for 8.
9%, which was a slight increase compared with 2019 (7.
5%), as follows Picture:

Seven, adverse drug reactions/events involving organ systems

Among the adverse drug reactions/events reported in 2020, the top 5 diseases affecting the organ system are skin and subcutaneous tissue diseases, immune system diseases, systemic diseases and various reactions at the administration site, respiratory system, chest and mediastinal diseases, The classification of various neurological diseases has been adjusted a bit compared with 2019.
The Medical Dictionary of Regulatory Activities (MedDRA) is used in the statistics of this year's report, and the World Health Organization Adverse Reaction Terminology (WHO-ART) has been used in the past
.
MedDRA is a standardized collection of international medical terminology compiled under the auspices of the International Coordinating Council for Technical Requirements for Human Drugs (ICH).
It is used for regulatory communication and data evaluation related to medical products for human use.
The author compared the proportions of the main organ systems involved.

.

1) Skin and subcutaneous tissue diseases accounted for 24.
2%, a slight decrease compared with 2019 (26.
9%);

2) Gastrointestinal diseases accounted for 27.
0%, a slight increase compared with 2019 (24.
6%);

3) Systemic diseases and various reactions at the site of administration accounted for 11.
1%, a slight increase compared with 2019 (10.
1%);

4) Various neurological diseases accounted for 9.
9%, a slight increase compared with 2019 (8.
9%);

5) Immune system diseases accounted for 2.
6%, a slight decrease compared with 2019 (3.
5%);

6) Respiratory system diseases accounted for 3.
5%, compared with 2019 (3.
5%), the proportion has not changed;

7) Vascular and lymph node diseases accounted for 2.
7%, a slight decrease compared with 2019 (2.
8%);

8) Others accounted for 12.
2%, a slight decrease compared with 2019 (12.
5%), as shown in the figure below:

  8.
Safety Risk Reminders for Elderly Patients

In 2020, the national adverse drug reaction monitoring network accounted for 30.
3% of elderly patients aged 65 and over, which was a slight increase from 2019
.
Severe reports received from elderly patients in 2020 accounted for 11.
5% of the total number of reports from elderly patients, which is higher than the proportion of serious reports in the overall report in 2020.
The statistical analysis results show that in the reports of adverse reactions/events of cardiovascular system medications, those aged 65 years and above The proportion of patients reported in the group and the proportion of severe reports were significantly higher than the level of patients in this age group in the overall report, suggesting that elderly patients are the main group of cardiovascular system medications, and medical staff and patients should pay attention to the risk of serious adverse reactions
.

Generally speaking, with the increase of age, the organ functions of the elderly will weaken to varying degrees, their metabolism will slow down, and the risk of adverse drug reactions will be greater.
Therefore, we should continue to pay attention to the safety of medication in the elderly.
The elderly should be particularly cautious in medication and treatment.
If you feel unwell after taking the medicine, consult your doctor or pharmacist.
If it is serious, seek medical advice in time
.

 references

[1]
About the author: Drip Sinan, male, senior engineer in biomedicine, based on the quality management of the biomedical industry, focusing on the biomedical industry
.