Analysis of the hardness, particle size and roll of the drying granulation machine.

Particulate medicine is not new to people, usually when cold will have their own shadow.
granulation machine, such as the dry granulation machine, plays a key role in particle production.
It is understood that dry granulation machine can achieve one-step granulation requirements, the complex processing links integrated, and completely closed processing, so that the processed particles in the appearance of improved, and easy to store and transport.
the solubility, porosity and surface area of the drug with a drying granulation machine.
" dry particle machines have improved the performance of the drug in every way.
recipients to meet the fast-paced needs of modern people.
"dry granulation machine" is a new type of granulation method developed after the second generation of granulation method "one-step granulation".
is an environmentally friendly granulation process that presses powder directly into particles.
inches in the pharmaceutical production process, dry granulation machine has been widely used, especially for wet, hot conditions easy to decompose or block the material granulation.
the granulation machine formed by the drying granulation machine may be directly pressed or filled into capsules.
dry particles and wet particles, less equipment required, less maintenance costs, small footprint, less production and processing costs.
inches, the dry particle method is simple compared to the wet particle method, reducing the GMP certification process.
however, some users reflect that dry granulation machine in the use of the process, often appear large particle hardness, uneven particle size, rolling and other major problems, affecting the granulation process.
first, the grain is great.
That industry insider said, encountered the problem of particle hardness, it is important to note that if the pressure of the dry granulation process is too high, the pressure of the dry particles is too hard, if the next tablet, due to the dry particles too hard, compression loss, resulting in the compression of the tablet, to greater pressure molding, machined vibration.
if it is a capsule, due to dry particles too hard, compression loss, resulting in the capsule filling process due to the column can not dump the material, so that the loading difference far beyond the limit.
is particle size uniformity.
inches in order to solve the problem of uniform particle distribution during pressing process, it is necessary to consider the following aspects: to ensure a uniform mix under high-speed stirring;
reasonable considerations, the uniformity of the product can be well controlled.
third, roll problem.
the roller is filled with cooling water, the rotating roller and the static cooling pipe have a dynamic sealing device.
, if the press is used for a long time, a leak can occur under great pressure.
At present, some manufacturers have improved the drum structure, so that the cooling water directly to the surface of the drum, can effectively reduce the surface temperature of the drum, but also reduce the possibility of leakage, should be said to be a progress.
industry due to material selection and processing process costs, many rollers after use, due to granulation pressure, after a period of time, roll wear, damage and other conditions, so many manufacturers after a period of use to buy rollers.
the market prospects of grain products and granules is huge, dry legal grain machine equipment market demand will also usher in growth.
this context, granulation machine manufacturers still need to improve process and structural design to meet the needs of users.
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