Analysis of the antitumor and immunomodulatory effects of tea polyphenols

Business club, June 27 - in 1995, the National Natural Science Foundation of China put "the anti-cancer mechanism of effective components of tea" as a key subject of bidding research, and clinical observation has also achieved good results The results showed that the main anticancer components of tea were tea polyphenols, various catechin monomers and tea pigments, the oxidation products of tea polyphenols Please look at the experiments of scientists: 1 The animal experiments of epidemiological research for many years have repeatedly proved that the preparation of tea and tea polyphenols can inhibit the formation and growth of malignant tumors induced by some physical factors or chemical carcinogens 2 The intervention test on cancer high-risk patients showed that drinking mixed tea (green tea freeze-dried product, tea polyphenol and tea pigment mixture) had protective effect on DNA damage of human oral mucosal epithelial cells, and had preventive effect on oral cancer; tea polyphenol had protective effect on DNA damage caused by smoking, and reduced the occurrence of cancer caused by smoking; tea polyphenol had protective effect on gastrointestinal cancer Certain preventive effect 3 Bone marrow suppression is a common side effect in the course of radiotherapy and chemotherapy Tea polyphenols have a significant protective effect on the Hemogram of patients treated with cisplatin, especially on the leukocyte count of patients treated with cisplatin 4 Animal experiments showed that tea polyphenols can significantly inhibit the formation, growth and malignant metastasis of skin and lung tumors in experimental mice; green tea extract can significantly inhibit the growth of gastrointestinal tumors in rats; tea polyphenols can significantly reduce the incidence of colon tumors in mice and the formation of aberrant glands in rats; green tea extract can significantly reduce the incidence of colon tumors in mice And EGCG (tea polyphenol monomer) also had a significant inhibitory effect on gastric cancer and colon cancer Tea polyphenols can also regulate immunity Animal experiments showed that tea polyphenols could improve the relative weight and cell number of spleen to adjust the immune function of tumor bearing mice, and promote the proliferation of immune cells by increasing the number of thymus or spleen cells per gram of ascites tumor and sarcoma mice.