An anti obesity drug derived from Capsicum has a bright future in animal experiments! But that doesn't mean eating more chili can lose weight!

July 22, 2018 / biool / - - in a new study from the school of pharmacy, Wyoming State University, a new drug derived from capsaicin can bring long-term weight loss effects and improve metabolic health in rats with a high fat diet Capsaicin is the substance that gives peppers spicy taste The drug, called metabocin, is designed to slow the release of capsaicin throughout the day, giving it an anti obesity effect without causing inflammation or side effects "We have seen significant improvements in blood glucose, blood cholesterol levels, insulin response and fatty liver symptoms," said lead researcher Dr baskaran thayagarajan, who explained how metabocin reverses many of the damaging effects of a high-fat diet He presented the results at this week's annual meeting of the society for food behavior research The oral drug metabocin, developed by the research team, targets a receptor called TRPV1, which is found in many fat cells Stimulation of TRPV1 receptors causes white fat cells to start burning energy instead of storing it, which theoretically leads to weight loss The important question researchers need to solve is whether the drug is effective for long-term use and whether its side effects will outweigh its benefits The mice in the study continued to take the medicine for 8 months, and there was no evidence of safety problems while losing weight Other ongoing experiments will see how long the effect can last "The drug has been shown to be safe and well tolerated in mice," concluded thayagarajan "Using metabocin as an effective anti obesity treatment is promising and meaningful for those who are struggling with obesity "Although these results will lead some people to think of reducing weight by eating more spicy food, it will not be as effective as they think Most of the capsaicin in spicy food is not well absorbed into the body, so it will not produce these effects For better absorption and sustained release, researchers modified capsaicin to metabocin Obesity is an increasingly serious public health problem, which will lead to metabolic diseases including type 2 diabetes, hypertension, atherosclerosis and heart disease One third of the world's people are now overweight or obese Improving exercise and diet is a standard recommendation, but it's difficult for most people to maintain for a long time, and rebound weight gain often occurs Wyoming researchers advocate continuing to promote long-term, effective treatments that reverse obesity and its effects on metabolism to help people who are looking for a healthier weight Original source: pharmaceutical and safety analyses of subchronic oral metallic feeding in rice, 26th annual meeting of the society for the study of aggressive behavior